General Cell Based Assays
Eurofins Discoverx PathHunter eXpress PROKR1 CHO-K1 β-Arrestin GPCR Assay, 10-Plate Kit. (93-0303E2CP0L)
The PathHunter PROKR1 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. prokinectin, EG-VEGF) based activation of PROKR1 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged PROKR1 and EA-tagged β-Arrestin-2. Activation of PROKR1 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress PTHR1 Activated GPCR Internalization Assay, 2pl Kit. (93-0770E3CP0M)
The PathHunter PTHR1 Activated GPCR internalization eXpress kit provides an easy to-use cell based assay to study drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This kit uses EFC technology to measure ligand-induced internalization of PTHR1 via detection of localization to the early endosome. The included cell line overexpresses EA-tagged β-Arrestin-2 as well as a ProLink-tagged early endosome protein and untagged PTHR1. Upon ligand-induced receptor activation, β-Arrestin-2 is recruited to the activated GPCR and the resulting PTHR1-arrestin complex is internalized to the early endosome, leading to production of EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Bio Rad Laboratories Adalimumab antibody | AbD18754_hIgG1, 0.1 mg
Human anti Adalimumab (Drug/Target Complex)Product Type- Monoclonal Antibody, Clone- AbD18754_hIgG1, Isotype- IgG1, Specificity- Adalimumab, Region- (DRUG/TARGET COMPLEX)
Cayman Chemical NADH Stndard 1.5mg
A derivative of 6-mercaptopurine has been used as a synthetic intermediate in the synthesis of compounds derived from azathioprine
Eurofins Discoverx PathHunter Human BMP-4 (BMPR1A/ACVR2B) Dimerization Cell-Based Assay Kit (U2OS)
The PathHunter Human BMP-4 (BMPR1A/ACVR2B) Stable Cell Line Dimerization Assay (U2OS) measures ligand-induced dimerization of BMPR1A/ACVR2B. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.